Alopecia, hair loss is a dermatologic disorder, and is a psychologically distressing condition. Androgen alopecia, which affects millions of men and women, is an androgen drived disorder. Here, plant Eclipta alba is evaluated for hair growth promoting potential activity in androgen –induced alopecia. Eclipta Alba (leaves) has been found to possess hair growth promoting activity in our laboratory (1). In the present study, it was envisaged to prepare herbal formulations containing petroleum ether extracts of Eclipta alba, methanolic extract of Eclipta alba and various fixed oil like mustard oil, coconut oil & sesame oil for evaluating the formulations for hair growth promoting potential activity. The method reported by matias is followed. Alopecia in albino mice was induced by subcutaneous injection of testosterone 1mg/day. Injection was given once daily 5days a week up to 12 weeks. Testosterone is known to produce the alopecia by thinning of hair coat, evenly develop into a bald area. Inhibition of alopecia by administration of Eclipta alba extract gel was evaluated by hair growth ignition & completion, area responded, anagen/ telogen ratio and histopathological skin section done for hair growth promoting potential activity. The animals treated with the methanolic extract of Eclipta alba shows higest number of hair follicle. The earliest hair growth seen in methanolic extract gel. In Methanolic extract of Eclipta alba and Standard drug 2% minoxidil average hair growth is 0.68 cm. All the experimental groups have shown a highly significant increase in Density of hair, Area responded and Hair bulb present as compared to control group. The time of responding is also early as compared to control group. In conclusion, methanolic extract of Eclipta alba definitely promotes hair growth by inducing anagen in telogen (resting) phase hair follicles. Animals treated with methanol extract of Eclipta alba showed better efficacy as compared to other formulated drugs.
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